A chance encounter leads to groundbreaking bladder exstrophy research
Professor Wei Cheng recalls the path that led to the discovery of the gene and mechanism responsible for bladder exstrophy in humans
“The strange appearance of something in the mouse’s abdomen”
It was at Sick Kids Toronto that my involvement with bladder exstrophy took an extraordinary turn. I’m a pediatric surgeon who has always maintained a passionate interest in research and I’m forever searching for answers as to why some children are born with congenital anomalies. Back in 2002, I was at the University of Toronto studying for a PhD in Developmental Biology. I chose Toronto specifically to pursue research into anal-rectal malformation, as the team at Sick Kids Research Institute had already developed a genetic mouse model for that condition.